Wishes are definitely one of CLAMP's favorite topics - Wish, X, XXXHOLiC, TRC...It's right up there with destiny, happiness, and strength.
To be more on topic, Wish is one of my favorite CLAMP series. I find it hilarious most of the time, and sweet at others. I agree with Duchessa and Rekall - it doesn't really have a sad ending.
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I've actually heard that CLAMP had originally planned to leave Shuichirou dead, but were persuaded to make it happier.
Koryu is my favorite in this series. He's a such a
brat. And Ruri and Hari amuse me so. I'm also not really into Kohaku/Shuichirou. I like Hisui/Kokuyo more, but I think my OTP for Wish was actually Ransho/Touki.
There is that annoying plot hole in the series, though.
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Everyone always goes on about how Shuichirou looks like Kokuyo, and we don't know where Shuichirou came from in the first place. I expected something to be made of that, but nothing ever is.
About the artwork, I think it's nice, though the shoulders on the men look extremely strange - the girls and the genderless people look good. The backgrounds and clothing designs and whatnot are quite as good as in the other CLAMP series.