I watched the anime. I liked the similarities between it and Card Captor Sakura; primarily, the music was done by Takayuki Negishi, and Masaya was voiced by Megumi Ogata (with both her voices, Yukito's for Masaya and Yue's for his alter-ego). This helped me warm up to the series much quicker than I normally would have.
The production values were wonderful. Everything was really well-detailed and colorful, using some modern animation techniques. It didn't burst at the rims with technology, which I guess is a good thing, keeping much of the image natural. The music for the most part was okay. It helps that Takayuki Negishi used the simple charm in his compositions to give Tokyo Mew Mew an attractive soundtrack; however, he obviously wasn't provided with many high-quality instruments, resorting to synth more often than in Card Captor Sakura. Regardless, it sets a fine mood for the show. The Engrish-speakers sounded way too unrealistic for me though, that's about all I have atmosphere problems with.
The whole idea of being infused with DNA to get their powers instead of being granted with them by some holy deity makes it seem like a mix of mahou shoujo/sci-fi, which is appreciated as it creates a new spin on the magical girl genre
The story itself is likable but plain; nothing special worth noting, but it doesn't ruin the experience. The characters are pretty deep, some more than others. Comedic factor is for the most part fresh and funny ("THIS IS A PEN"). And the enemy gives you a reason to care about them. Unfortunately the ending was highly predictable, and leaves us wondering what happens with no obvious conclusion to a particular part of the story.
I find it strange yet highly amusing that five sixths of our main cast is named after an edible of some sort, four of whom are named as so in English rather than Japanese.
I enjoyed the opening theme, which had a vocalist that put effort and emotion into her singing (sometimes bad, sometimes good), which accompanied a catchy tune and a good video sequence; the ending, which featured all the Mew Mew cast as singers, was too super hyper for my liking, but has its merits.
All in all, I think it's okay. I mostly watched it for the colorful cast, not so much for the story, and in that field I was satisfied. Not an interest I'd pursue long-term, but it was a good experience.
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