I love Full Moon wo Sagashite a lot, even though both the manga and the anime are, in a way, completely different although it has the same basic plot.
Spoiler for both anime and manga comparisons.
Show content
The anime's ending has a lot to be desired. As much as Meroko became an angel, I still felt that she deserved much more than that. Same goes for Izumi... Which makes the manga's ending more entertaining.
But then again, I don't know why, but Mitsuki's attitude in the manga really bugged me. She acted a little spoilt there... and is such a cry baby unlike the anime Mistuki, who, even through her tears, continued to prevail in her attempts to reach her dreams.
I suppose this could be because the Mitsuki in the manga had already known that Eichi's dead. But that still couldn't make me like the manga Mitsuki more than the anime Mitsuki. But that's just me...
I loved the guys in the manga. Eichi looked a lot more human (not like the much worshipped Eichi in the anime) and there's so many things you learn about Takuto and Izumi, you can't help but fall in love with these two. My only gripe is Mitsuki and, sadly... Meroko.
Overall, the manga had a better way of putting the story. But where the manga lacked, the anime fulfilled and where the anime lacked, the manga fulfilled.
If you liked the anime, get the manga. If you liked the manga, get the anime. You will not be disappointed. ^^